Phospholipid-modified PEI-based nanocarriers for in vivo siRNA therapeutics against multi-drug resistant tumors

Multidrug resistance (MDR) mediated by P-glycoprotein overexpression in solid tumors is a major factor in the failure of many forms of chemotherapy. Here, we evaluated phospholipid-modified, low molecular weight polyethylenimine (DOPE-PEI) nanocarriers for intravenous delivery of anti-P-pg siRNA to...

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Bibliografiska uppgifter
I publikationen:Gene Ther
Huvudupphovsmän: Essex, Sean, Navarro, Gemma, Sabhachandani, Pooja, Chordia, Aabha, Trivedi, Malav, Movassaghian, Sara, Torchilin, Vladimir P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352110/
https://ncbi.nlm.nih.gov/pubmed/25354685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.97
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