G-->A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription.

The quasispecies model for RNA viruses predicts the existence of a replication error threshold beyond which there is a melting or total loss of sequence information. Retroviral G-->A hypermutation is probably an example. Here it is shown that G-->A transitions may occur in both GpG and GpA dinucleot...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Vartanian, J P, Meyerhans, A, Sala, M, Wain-Hobson, S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512722/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.8.3092
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