2-Methoxyestradiol Induces Vasodilation by Stimulating NO Release via PPARγ/PI3K/Akt Pathway

The endogenous estradiol metabolite 2-methoxyestradiol (2-ME) reduces atherosclerotic lesion formation, while the underlying mechanisms remain obscure. In this work, we investigated the vasodilatory effect of 2-ME and the role of nitric oxide (NO) involved. In vivo studies using noninvasive tail-cuf...

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發表在:PLoS One
Main Authors: Chen, Weiyu, Cui, Yuhong, Zheng, Shuhui, Huang, Jinghe, Li, Ping, Simoncini, Tommaso, Zhang, Yongfu, Fu, Xiaodong
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351983/
https://ncbi.nlm.nih.gov/pubmed/25748432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118902
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