PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

Transforming growth factor beta (TGFβ) induced differentiation of human lung fibroblasts to myofibroblasts is a key event in the pathogenesis of pulmonary fibrosis. Although the typical TGFβ signaling pathway involves the Smad family of transcription factors, we have previously reported that peroxis...

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Autors principals: Kulkarni, Ajit A., Thatcher, Thomas H., Olsen, Keith C., Maggirwar, Sanjay B., Phipps, Richard P., Sime, Patricia J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017065/
https://ncbi.nlm.nih.gov/pubmed/21253589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015909
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