Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced Infectivity

Trypanosoma brucei variant surface glycoproteins (VSG) are glycosylated by both paucimannose and oligomannose structures which are involved in the formation of a protective barrier against the immune system. Here, we report that the stinging nettle lectin (UDA), with predominant N-acetylglucosamine-...

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Опубликовано в: :PLoS Negl Trop Dis
Главные авторы: Castillo-Acosta, Víctor M., Ruiz-Pérez, Luis M., Van Damme, Els J. M., Balzarini, Jan, González-Pacanowska, Dolores
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351956/
https://ncbi.nlm.nih.gov/pubmed/25746926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003612
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