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VSG switching in Trypanosoma brucei: antigenic variation analysed using RNAi in the absence of immune selection
Trypanosoma brucei relies on antigenic variation of its Variant Surface Glycoprotein (VSG) coat for survival. We show that VSG switching can be efficiently studied in vitro using VSG RNAi in place of an immune system to select for switch variants. Contrary to models predicting an instant switch afte...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1618954/ https://ncbi.nlm.nih.gov/pubmed/16135228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2005.04795.x |
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