Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial

BACKGROUND: Osteoarthritis (OA) is the fastest growing cause of disability worldwide. Current treatments for OA are severely limited and a large proportion of people with OA live in constant, debilitating pain. There is therefore an urgent need for novel treatments to reduce pain. Synovitis is highl...

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Dettagli Bibliografici
Pubblicato in:Trials
Autori principali: Kingsbury, Sarah R, Tharmanathan, Puvan, Arden, Nigel K, Batley, Michael, Birrell, Fraser, Cocks, Kim, Doherty, Michael, Edwards, Chris J, Garrood, Toby, Grainger, Andrew J, Green, Michael, Hewitt, Catherine, Hughes, Rod, Moots, Robert, O’Neill, Terence W, Roddy, Edward, Scott, David L, Watt, Fiona E, Torgerson, David J, Conaghan, Philip G
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Study Protocol
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351849/
https://ncbi.nlm.nih.gov/pubmed/25872649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-0602-8
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