Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial

BACKGROUND: Osteoarthritis (OA) is the fastest growing cause of disability worldwide. Current treatments for OA are severely limited and a large proportion of people with OA live in constant, debilitating pain. There is therefore an urgent need for novel treatments to reduce pain. Synovitis is highl...

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Vydáno v:Trials
Hlavní autoři: Kingsbury, Sarah R, Tharmanathan, Puvan, Arden, Nigel K, Batley, Michael, Birrell, Fraser, Cocks, Kim, Doherty, Michael, Edwards, Chris J, Garrood, Toby, Grainger, Andrew J, Green, Michael, Hewitt, Catherine, Hughes, Rod, Moots, Robert, O’Neill, Terence W, Roddy, Edward, Scott, David L, Watt, Fiona E, Torgerson, David J, Conaghan, Philip G
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Study Protocol
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351849/
https://ncbi.nlm.nih.gov/pubmed/25872649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-0602-8
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