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A [(3)H]amine congener of 1,3-dipropyl-8-phenylxanthine: A new radioligand for A2 adenosine receptors of human platelets

A xanthine amine congener (XAC), an amine-functionalized derivative of 1,3-dipropyl-8-phenylxanthine, is an antagonist ligand for A2 adenosine receptors of human platelets. XAC inhibited 5′-N-ethylcarboxamidoadenosine (NECA)-induced stimulation of adenylate cyclase activity with a K(B) of 24 nM. [(3...

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發表在:FEBS Lett
Main Authors: Ukena, Dieter, Jacobson, Kenneth A., Kirk, Kenneth L., Daly, John W.
格式: Artigo
語言:Inglês
出版: 1986
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351550/
https://ncbi.nlm.nih.gov/pubmed/3009222
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