Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas

Acinar cell carcinoma of the pancreas is a rare tumor with a poor prognosis. Compared to pancreatic ductal adenocarcinoma, its molecular features are poorly known. We studied a total of 11 acinar cell carcinomas, including 3 by exome and 4 by target sequencing. Exome sequencing revealed 65 nonsynony...

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Udgivet i:Sci Rep
Main Authors: Furukawa, Toru, Sakamoto, Hitomi, Takeuchi, Shoko, Ameri, Mitra, Kuboki, Yuko, Yamamoto, Toshiyuki, Hatori, Takashi, Yamamoto, Masakazu, Sugiyama, Masanori, Ohike, Nobuyuki, Yamaguchi, Hiroshi, Shimizu, Michio, Shibata, Noriyuki, Shimizu, Kyoko, Shiratori, Keiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351513/
https://ncbi.nlm.nih.gov/pubmed/25743105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08829
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