Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL

Chronic lymphocytic leukemia (CLL) is a common B-cell malignancy characterized by a highly variable course and outcome. The disease is believed to be driven by B-cell receptor (BCR) signals generated by external antigens and/or cell-autonomous BCR interactions, but direct in vivo evidence for this i...

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Publicat a:Blood
Autors principals: Iacovelli, Stefano, Hug, Eva, Bennardo, Sara, Duehren-von Minden, Marcus, Gobessi, Stefania, Rinaldi, Andrea, Suljagic, Mirza, Bilbao, Daniel, Bolasco, Giulia, Eckl-Dorna, Julia, Niederberger, Verena, Autore, Francesco, Sica, Simona, Laurenti, Luca, Wang, Hongsheng, Cornall, Richard J., Clarke, Stephen H., Croce, Carlo M., Bertoni, Francesco, Jumaa, Hassan, Efremov, Dimitar G.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351506/
https://ncbi.nlm.nih.gov/pubmed/25564405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-587790
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