Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

A polymorphic variant of the phosphatase PTPN22 has been associated with increased risk for multiple autoimmune diseases. The risk allele is thought to function by diminishing antigen-receptor signals responsible for negative selection of autoreactive lymphocytes. We now show that PTPN22 is markedly...

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Detalhes bibliográficos
Main Authors: Negro, Roberto, Gobessi, Stefania, Longo, Pablo G., He, Yantao, Zhang, Zhong-Yin, Laurenti, Luca, Efremov, Dimitar G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383194/
https://ncbi.nlm.nih.gov/pubmed/22569400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-403162
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