WNT Signaling Suppression in the Senescent Human Thymus

Human thymus is completely developed in late fetal stages and its function peaks in newborns. After the first year of life, the thymus undergoes a progressive atrophy that dramatically decreases de novo T-lymphocyte maturation. Hormonal signaling and changes in the microRNA expression network are id...

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Bibliografiske detaljer
Udgivet i:J Gerontol A Biol Sci Med Sci
Main Authors: Ferrando-Martínez, Sara, Ruiz-Mateos, Ezequiel, Dudakov, Jarrod A., Velardi, Enrico, Grillari, Johannes, Kreil, David P., Muñoz-Fernandez, Mª Ángeles, van den Brink, Marcel R. M., Leal, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351388/
https://ncbi.nlm.nih.gov/pubmed/24657825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glu030
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