Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor

AIMS: Elevated activity of urokinase plasminogen activator (uPA) and MMPs in human arteries is associated with accelerated atherosclerosis, aneurysms, and plaque rupture. We used Apoe-null mice with macrophage-specific uPA overexpression (SR-uPA mice; a well-characterized model of protease-accelerat...

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Publicat a:Cardiovasc Res
Autors principals: Hu, Jie Hong, Touch, Phanith, Zhang, Jingwan, Wei, Hao, Liu, Shihui, Lund, Ida K., Høyer-Hansen, Gunilla, Dichek, David A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351369/
https://ncbi.nlm.nih.gov/pubmed/25616415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv007
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