A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy()

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers principally because of early invasion and metastasis. The epidermal growth factor receptor (EGFR) is essential for PDAC development even in the presence of Kras, but its inhibition with erlotinib gives only a modest clinical r...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Cardone, Rosa Angela, Greco, Maria Raffaella, Zeeberg, Katrine, Zaccagnino, Angela, Saccomano, Mara, Bellizzi, Antonia, Bruns, Philipp, Menga, Marta, Pilarsky, Christian, Schwab, Albrecht, Alves, Frauke, Kalthoff, Holger, Casavola, Valeria, Reshkin, Stephan Joel
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351296/
https://ncbi.nlm.nih.gov/pubmed/25748234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.12.003
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