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PKCη/Rdx-driven Phosphorylation of PDK1: A Novel Mechanism Promoting Cancer Cell Survival and Permissiveness for Parvovirus-induced Lysis

The intrinsic oncotropism and oncosuppressive activities of rodent protoparvoviruses (PVs) are opening new prospects for cancer virotherapy. Virus propagation, cytolytic activity, and spread are tightly connected to activation of the PDK1 signaling cascade, which delays stress-induced cell death and...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Bär, Séverine, Rommelaere, Jean, Nüesch, Jürg P. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351090/
https://ncbi.nlm.nih.gov/pubmed/25742010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004703
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