Blockade of PD-1/PD-L1 Promotes Adoptive T-Cell Immunotherapy in a Tolerogenic Environment

Adoptive cellular immunotherapy using in vitro expanded CD8(+) T cells shows promise for tumour immunotherapy but is limited by eventual loss of function of the transferred T cells through factors that likely include inactivation by tolerogenic dendritic cells (DC). The co-inhibitory receptor progra...

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Bibliographic Details
Published in:PLoS One
Main Authors: Blake, Stephen J. P., Ching, Alan L. H., Kenna, Tony J., Galea, Ryan, Large, Justin, Yagita, Hideo, Steptoe, Raymond J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351071/
https://ncbi.nlm.nih.gov/pubmed/25741704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119483
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