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Detection of Peri-Synaptic Amyloid-β Pyroglutamate Aggregates in Early Stages of Alzheimer’s Disease and in AβPP Transgenic Mice Using a Novel Monoclonal Antibody
The neurodegenerative pathology in patients with Alzheimer’s disease (AD) has been associated with the progressive accumulation of aggregated and post-translationally modified amyloid-β (Aβ) species. Among them, recent studies indicate that the pyroglutamate modification of Aβ (pE(3)Aβ) catalyzed by...
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| Publicado no: | J Alzheimers Dis |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4350934/ https://ncbi.nlm.nih.gov/pubmed/22064070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-111208 |
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