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Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited nephropathy responsible for 4%–10% of end-stage renal disease cases. Mutations in the genes encoding polycystin-1 (PC1, PKD1) or polycystin-2 (PC2, PKD2) cause ADPKD, and PKD1 mutations are associated with more severe renal d...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gainullin, Vladimir G., Hopp, Katharina, Ward, Christopher J., Hommerding, Cynthia J., Harris, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350419/
https://ncbi.nlm.nih.gov/pubmed/25574838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76972
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