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Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited nephropathy responsible for 4%–10% of end-stage renal disease cases. Mutations in the genes encoding polycystin-1 (PC1, PKD1) or polycystin-2 (PC2, PKD2) cause ADPKD, and PKD1 mutations are associated with more severe renal d...
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Publicado no: | J Clin Invest |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Clinical Investigation
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4350419/ https://ncbi.nlm.nih.gov/pubmed/25574838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76972 |
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