Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions

Incidence and mortality of bacterial meningitis are strongly increased in aged compared to younger adults demanding new strategies to improve prevention and therapy of bacterial central nervous system (CNS) infections the elderly. Here, we established a geriatric mouse model for an intracerebral E....

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Schütze, Sandra, Ribes, Sandra, Kaufmann, Annika, Manig, Anja, Scheffel, Jörg, Redlich, Sandra, Bunkowski, Stephanie, Hanisch, Uwe-Karsten, Brück, Wolfgang, Nau, Roland
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
Soggetti:
Gerotarget (Focus on Aging): Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350342/
https://ncbi.nlm.nih.gov/pubmed/25528768
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