The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma

New targets for Ewing sarcoma (ES) patients are urgently needed. Therefore, we investigated the expression and genetic aberrations of the oncogenic receptor tyrosine kinase (RTK) AXL in ES and determined the efficacy of AXL targeting on cell viability and migration. First, AXL and Gas6 (ligand) mRNA...

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Vydáno v:Oncotarget
Hlavní autoři: Fleuren, Emmy D.G., Hillebrandt-Roeffen, Melissa H.S., Flucke, Uta E., te Loo, D. Maroeska W.M., Boerman, Otto C., van der Graaf, Winette T.A., Versleijen-Jonkers, Yvonne M.H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350331/
https://ncbi.nlm.nih.gov/pubmed/25528764
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