Cutaneous Na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense

Immune cells regulate a hypertonic microenvironment in the skin; however, the biological advantage of increased skin Na(+) concentrations is unknown. We found that Na(+) accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania major as a m...

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Publicado no:Cell Metab
Main Authors: Jantsch, Jonathan, Schatz, Valentin, Friedrich, Diana, Schröder, Agnes, Kopp, Christoph, Siegert, Isabel, Maronna, Andreas, Wendelborn, David, Linz, Peter, Binger, Katrina J., Gebhardt, Matthias, Heinig, Matthias, Neubert, Patrick, Fischer, Fabian, Teufel, Stefan, David, Jean-Pierre, Neufert, Clemens, Cavallaro, Alexander, Rakova, Natalia, Küper, Christoph, Beck, Franz-Xaver, Neuhofer, Wolfgang, Muller, Dominik N., Schuler, Gerold, Uder, Michael, Bogdan, Christian, Luft, Friedrich C., Titze, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350016/
https://ncbi.nlm.nih.gov/pubmed/25738463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.02.003
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