Secretome Analysis of an Osteogenic Prostate Tumor Identifies Complex Signaling Networks Mediating Cross-talk of Cancer and Stromal Cells Within the Tumor Microenvironment

A distinct feature of human prostate cancer (PCa) is the development of osteoblastic (bone-forming) bone metastases. Metastatic growth in the bone is supported by factors secreted by PCa cells that activate signaling networks in the tumor microenvironment that augment tumor growth. To better underst...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Lee, Yu-Chen, Gajdosik, Martina Srajer, Josic, Djuro, Clifton, James G., Logothetis, Christopher, Yu-Lee, Li-Yuan, Gallick, Gary E., Maity, Sankar N., Lin, Sue-Hwa
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349970/
https://ncbi.nlm.nih.gov/pubmed/25527621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.039909
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