Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice

AIM: Defects in fatty acid metabolism contribute to the pathogenesis of insulin resistance and obesity. In this study, we investigated the effects of a novel compound yhhu981 on fatty acid metabolism in vitro and in vivo. METHODS: The capacity to stimulate fatty acid oxidation was assessed in C2C12...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Zeng, Hong-liang, Huang, Su-ling, Xie, Fu-chun, Zeng, Li-min, Hu, You-hong, Leng, Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349926/
https://ncbi.nlm.nih.gov/pubmed/25732571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.147
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