The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells

AIM: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Augustin, Ewa, Skwarska, Anna, Weryszko, Anna, Pelikant, Iwona, Sankowska, Ewa, Borowa-Mazgaj, Barbara
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349925/
https://ncbi.nlm.nih.gov/pubmed/25640477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.142
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