Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome

Somatic mutations in the spliceosome gene ZRSR2 — located on the X chromosome — are associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of 3΄ splice site during the early stages of spliceosome assembly; however, its precise role in RNA splicing has remained unclear....

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Publicado no:Nat Commun
Main Authors: Madan, Vikas, Kanojia, Deepika, Li, Jia, Okamoto, Ryoko, Sato-Otsubo, Aiko, Kohlmann, Alexander, Sanada, Masashi, Grossmann, Vera, Sundaresan, Janani, Shiraishi, Yuichi, Miyano, Satoru, Thol, Felicitas, Ganser, Arnold, Yang, Henry, Haferlach, Torsten, Ogawa, Seishi, Koeffler, H. Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349895/
https://ncbi.nlm.nih.gov/pubmed/25586593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7042
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