Enhanced CD8 T Cell Responses through GITR-Mediated Costimulation Resolve Chronic Viral Infection

Chronic infections are characterized by the inability to eliminate the persisting pathogen and often associated with functional impairment of virus-specific T-cell responses. Costimulation through Glucocorticoid-induced TNFR-related protein (GITR) can increase survival and function of effector T cel...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Pascutti, Maria Fernanda, Geerman, Sulima, Slot, Edith, van Gisbergen, Klaas P. J. M., Boon, Louis, Arens, Ramon, van Lier, Rene A. W, Wolkers, Monika C., Nolte, Martijn A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349659/
https://ncbi.nlm.nih.gov/pubmed/25738498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004675
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