In vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum; their antiplasmodial action in rodent malaria model

BACKGROUND: Emergence of drug-resistant parasite strains has surfaced as a major obstacle in attempts to ameliorate malaria. Current treatment regimen of malaria relies on the concept of artemisinin-based combination therapy (ACT). METHODS: Fluoroquinolone analogues, compounds 10, 12 and 18 were inv...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Agarwal, Drishti, Sharma, Manish, Dixit, Sandeep K, Dutta, Roshan K, Singh, Ashok K, Gupta, Rinkoo D, Awasthi, Satish K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349624/
https://ncbi.nlm.nih.gov/pubmed/25652883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-0561-2
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