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Preimplantation genetic diagnosis (PGD) for genetic prion disorder due to F198S mutation in PRNP gene

IMPORTANCE: To describe the first case of preimplantation genetic diagnosis (PGD) and in vitro fertilization (IVF) performed for the prevention of genetic prion disease in a 27-year-old asymptomatic woman with a known family history of Gerstmann-Sträussler-Sheinker syndrome (GSS). OBSERVATIONS: PGD...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Uflacker, Alice, Doraiswamy, P. Murali, Rechitsky, Svetlana, See, Tricia, Geschwind, Michael, Tur-Kaspa, Ilan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349573/
https://ncbi.nlm.nih.gov/pubmed/24493558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2013.5884
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