Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling

In mouse embryos at mid-gestation, primordial germ cells (PGCs) undergo licensing to become gametogenesis-competent cells (GCCs), gaining the capacity for meiotic initiation and sexual differentiation. GCCs then initiate either oogenesis or spermatogenesis in response to gonadal cues. Germ cell lice...

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發表在:PLoS Genet
Main Authors: Hu, Yueh-Chiang, Nicholls, Peter K., Soh, Y. Q. Shirleen, Daniele, Joseph R., Junker, Jan Philipp, van Oudenaarden, Alexander, Page, David C.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349450/
https://ncbi.nlm.nih.gov/pubmed/25739037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005019
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