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Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia
Hypoxia has been previously shown to inhibit the dihydroceramide (DHC) desaturase, leading to the accumulation of DHC. In this study, we used metabolic labeling with [3H]-palmitate, HPLC/MS/MS analysis, and specific inhibitors to show numerous sphingolipid changes after oxygen deprivation in cerebra...
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| Опубликовано в: : | J Neurochem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4349382/ https://ncbi.nlm.nih.gov/pubmed/25060904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12836 |
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