Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase-3

Brain glycogen synthase kinase-3 (GSK3) is hyperactive in several neurological conditions that involve impairments in both cognition and neurogenesis. This raises the hypotheses that hyperactive GSK3 may directly contribute to impaired cognition, and that this may be related to deficiencies in neura...

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Bibliographic Details
Published in:Front Behav Neurosci
Main Authors: Pardo, Marta, King, Margaret K., Perez-Costas, Emma, Melendez-Ferro, Miguel, Martinez, Ana, Beurel, Eleonore, Jope, Richard S.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349180/
https://ncbi.nlm.nih.gov/pubmed/25788881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2015.00055
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