Role of glutamine-117 in the ribonucleolytic activity of human angiogenin.
The crystal structure of human angiogenin (reported in the preceding paper in this issue) reveals that the site that corresponds to the pyrimidine binding site of RNase A is obstructed by Gln-117. Mutation of this residue to Ala and Gly is here found to increase activity 11- to 18-fold and 21- to 30...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43486/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8159680/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.8.2920 |
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