Effect of the excipient concentration on the pharmacokinetics of PM181104, a novel antimicrobial thiazolyl cyclic peptide antibiotic, following intravenous administration to mice

Thiazolyl cyclic peptide antibiotics are known for their poor aqueous solubility and unfavorable pharmacokinetics (PK) and hence pose challenging tasks in developing these antibiotics as clinical candidates. In the current paper, we report a possible way to address these challenges with exemplificat...

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Publicado no:Results Pharma Sci
Principais autores: Yemparala, Vijayaphanikumar, Damre, Anagha A., Manohar, Venkat, Sharan Singh, Kishori, Mahajan, Girish B., Sawant, Satish N., Deokule, Tanaji, Sivaramakrishnan, H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348513/
https://ncbi.nlm.nih.gov/pubmed/25756005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.rinphs.2014.09.001
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