PRIMAL: Fast and Accurate Pedigree-based Imputation from Sequence Data in a Founder Population

Founder populations and large pedigrees offer many well-known advantages for genetic mapping studies, including cost-efficient study designs. Here, we describe PRIMAL (PedigRee IMputation ALgorithm), a fast and accurate pedigree-based phasing and imputation algorithm for founder populations. PRIMAL...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Livne, Oren E., Han, Lide, Alkorta-Aranburu, Gorka, Wentworth-Sheilds, William, Abney, Mark, Ober, Carole, Nicolae, Dan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348507/
https://ncbi.nlm.nih.gov/pubmed/25735005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004139
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