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U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats
Sex differences are well known in cerebral ischemia and may impact the effect of stroke treatments. In male rats, the MEK1/2 inhibitor U0126 reduces ischemia-induced endothelin type B (ET(B)) receptor upregulation, infarct size and improves acute neurologic function after experimental stroke. Howeve...
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| Publicado no: | J Cereb Blood Flow Metab |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4348385/ https://ncbi.nlm.nih.gov/pubmed/25492115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.217 |
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