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Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration

The intranasal administration route is increasingly being used as a noninvasive method to bypass the blood–brain barrier because evidence suggests small fractions of nasally applied macromolecules may reach the brain directly via olfactory and trigeminal nerve components present in the nasal mucosa....

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Dades bibliogràfiques
Publicat a:J Cereb Blood Flow Metab
Autors principals: Lochhead, Jeffrey J, Wolak, Daniel J, Pizzo, Michelle E, Thorne, Robert G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348383/
https://ncbi.nlm.nih.gov/pubmed/25492117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.215
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