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Homer Protein–Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling and Affects Hyperexcitability in a Mouse Model of Fragile X Syndrome
The Fmr1 knock-out mouse model of fragile X syndrome (Fmr1(−/y)) has an epileptogenic phenotype that is triggered by group I metabotropic glutamate receptor (mGluR) activation. We found that a membrane-permeable peptide that disrupts mGluR5 interactions with long-form Homers enhanced mGluR-induced e...
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| Publicado en: | J Neurosci |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Society for Neuroscience
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4348189/ https://ncbi.nlm.nih.gov/pubmed/25740522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4499-14.2015 |
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