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Conditional Trimerization and Lytic Activity of HIV-1 gp41 Variants containing the Membrane-Associated Segments

Fusion of host and viral membranes is a critical step during infection by membrane-bound viruses. The HIV-1 glycoproteins gp120 (surface subunit) and gp41 (fusion subunit) represent the prototypic system for studying this process; in the prevailing model, the gp41 ectodomain forms a trimeric six-hel...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Dai, Zhou, Tao, Yisong, Liu, Nina, Brenowitz, Michael D., Girvin, Mark E., Lai, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348151/
https://ncbi.nlm.nih.gov/pubmed/25658332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501376f
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