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PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma
BACKGROUND: Preclinical studies suggest that Reed–Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune detection. In classic Hodgkin's lymphoma, alterations in chromosome 9p24.1 increase the abundance of the PD-1 ligands, PD-L1 and PD-L2, and promote their induction thr...
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Publicado no: | N Engl J Med |
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Main Authors: | , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4348009/ https://ncbi.nlm.nih.gov/pubmed/25482239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1411087 |
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