PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

BACKGROUND: Preclinical studies suggest that Reed–Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune detection. In classic Hodgkin's lymphoma, alterations in chromosome 9p24.1 increase the abundance of the PD-1 ligands, PD-L1 and PD-L2, and promote their induction thr...

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Bibliographic Details
Published in:N Engl J Med
Main Authors: Ansell, Stephen M., Lesokhin, Alexander M., Borrello, Ivan, Halwani, Ahmad, Scott, Emma C., Gutierrez, Martin, Schuster, Stephen J., Millenson, Michael M., Cattry, Deepika, Freeman, Gordon J., Rodig, Scott J., Chapuy, Bjoern, Ligon, Azra H., Zhu, Lili, Grosso, Joseph F., Kim, Su Young, Timmerman, John M., Shipp, Margaret A., Armand, Philippe
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348009/
https://ncbi.nlm.nih.gov/pubmed/25482239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1411087
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