PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

BACKGROUND: Preclinical studies suggest that Reed–Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune detection. In classic Hodgkin's lymphoma, alterations in chromosome 9p24.1 increase the abundance of the PD-1 ligands, PD-L1 and PD-L2, and promote their induction thr...

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Detaylı Bibliyografya
Yayımlandı:N Engl J Med
Asıl Yazarlar: Ansell, Stephen M., Lesokhin, Alexander M., Borrello, Ivan, Halwani, Ahmad, Scott, Emma C., Gutierrez, Martin, Schuster, Stephen J., Millenson, Michael M., Cattry, Deepika, Freeman, Gordon J., Rodig, Scott J., Chapuy, Bjoern, Ligon, Azra H., Zhu, Lili, Grosso, Joseph F., Kim, Su Young, Timmerman, John M., Shipp, Margaret A., Armand, Philippe
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348009/
https://ncbi.nlm.nih.gov/pubmed/25482239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1411087
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