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Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas

The mitogen-activated protein kinase (MAPK) pathway is known to play a key role in the initiation and maintenance of many tumors as well as normal development. This often occurs through mutation of the genes encoding RAS and RAF proteins which are involved in signal transduction in this pathway. BRA...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Penman, Catherine Louise, Faulkner, Claire, Lowis, Stephen P., Kurian, Kathreena M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347423/
https://ncbi.nlm.nih.gov/pubmed/25785246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00054
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