Pleiotrophin mediates hematopoietic regeneration via activation of RAS

Hematopoietic stem cells (HSCs) are highly susceptible to ionizing radiation–mediated death via induction of ROS, DNA double-strand breaks, and apoptotic pathways. The development of therapeutics capable of mitigating ionizing radiation–induced hematopoietic toxicity could benefit both victims of ac...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Himburg, Heather A., Yan, Xiao, Doan, Phuong L., Quarmyne, Mamle, Micewicz, Eva, McBride, William, Chao, Nelson J., Slamon, Dennis J., Chute, John P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2014
Materias:
Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347246/
https://ncbi.nlm.nih.gov/pubmed/25250571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76838
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