Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation

Microbial clearance by eukaryotes relies on complex and coordinated processes that remain poorly understood. The gasotransmitter carbon monoxide (CO) is generated by the stress-responsive enzyme heme oxygenase-1 (HO-1, encoded by Hmox1), which is highly induced in macrophages in response to bacteria...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wegiel, Barbara, Larsen, Rasmus, Gallo, David, Chin, Beek Yoke, Harris, Clair, Mannam, Praveen, Kaczmarek, Elzbieta, Lee, Patty J., Zuckerbraun, Brian S., Flavell, Richard, Soares, Miguel P., Otterbein, Leo E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347244/
https://ncbi.nlm.nih.gov/pubmed/25295542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72853
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