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Colon distention induces persistent visceral hypersensitivity by mechanotranscription of pain mediators in colonic smooth muscle cells

Abdominal pain and distention are major complaints in irritable bowel syndrome. Abdominal distention is mainly attributed to intraluminal retention of gas or solid contents, which may cause mechanical stress to the gut wall. Visceral hypersensitivity (VHS) may account for abdominal pain. We sought t...

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Pubblicato in:Am J Physiol Gastrointest Liver Physiol
Autori principali: Lin, You-Min, Fu, Yu, Wu, Chester C., Xu, Guang-Yin, Huang, Li-Yen, Shi, Xuan-Zheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346753/
https://ncbi.nlm.nih.gov/pubmed/25540231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00328.2014
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