Colon distention induces persistent visceral hypersensitivity by mechanotranscription of pain mediators in colonic smooth muscle cells

Abdominal pain and distention are major complaints in irritable bowel syndrome. Abdominal distention is mainly attributed to intraluminal retention of gas or solid contents, which may cause mechanical stress to the gut wall. Visceral hypersensitivity (VHS) may account for abdominal pain. We sought t...

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Detalles Bibliográficos
Publicado en:Am J Physiol Gastrointest Liver Physiol
Main Authors: Lin, You-Min, Fu, Yu, Wu, Chester C., Xu, Guang-Yin, Huang, Li-Yen, Shi, Xuan-Zheng
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2014
Assuntos:
Neuroregulation and Motility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346753/
https://ncbi.nlm.nih.gov/pubmed/25540231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00328.2014
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