Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

Roquin is an RNA-binding protein that prevents autoimmunity and inflammation via repression of bound target mRNAs such as inducible costimulator (Icos). When Roquin is absent or mutated (Roquin(san)), Icos is overexpressed in T cells. Here we show that Roquin enhances Dicer-mediated processing of pr...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Srivastava, Monika, Duan, Guowen, Kershaw, Nadia J., Athanasopoulos, Vicki, Yeo, Janet H. C., Ose, Toyoyuki, Hu, Desheng, Brown, Simon H. J., Jergic, Slobodan, Patel, Hardip R., Pratama, Alvin, Richards, Sashika, Verma, Anil, Jones, E. Yvonne, Heissmeyer, Vigo, Preiss, Thomas, Dixon, Nicholas E., Chong, Mark M. W., Babon, Jeffrey J., Vinuesa, Carola G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346627/
https://ncbi.nlm.nih.gov/pubmed/25697406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7253
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