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Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis
Roquin is an RNA-binding protein that prevents autoimmunity and inflammation via repression of bound target mRNAs such as inducible costimulator (Icos). When Roquin is absent or mutated (Roquin(san)), Icos is overexpressed in T cells. Here we show that Roquin enhances Dicer-mediated processing of pr...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Pub. Group
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4346627/ https://ncbi.nlm.nih.gov/pubmed/25697406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7253 |
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