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T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

The T-cell antigen CD28 provides a costimulatory signal that is required for T-cell proliferation. T-cell receptor zeta/CD3 engagement without CD28 ligation leads to a state of nonresponsiveness/anergy, thereby implicating CD28 in the control of peripheral tolerance to foreign antigens or tumors. A...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Prasad, K V, Cai, Y C, Raab, M, Duckworth, B, Cantley, L, Shoelson, S E, Rudd, C E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43465/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8146197/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.7.2834
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