Rapid depletion of B lymphocytes by ultra-low-dose rituximab delivered intrathecally

OBJECTIVE: We are conducting an open-label phase 1b study on the efficacy of intrathecal (IT) administration of rituximab, provided via an Ommaya reservoir, for the treatment of progressive multiple sclerosis (PMS). The objective of this initial study was to monitor B lymphocytes in peripheral blood...

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Bibliografiske detaljer
Udgivet i:Neurol Neuroimmunol Neuroinflamm
Main Authors: Svenningsson, Anders, Bergman, Joakim, Dring, Ann, Vågberg, Mattias, Birgander, Richard, Lindqvist, Thomas, Gilthorpe, Jonathan, Bergenheim, Tommy
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345631/
https://ncbi.nlm.nih.gov/pubmed/25745637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000079
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