C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice

In murine senile amyloidosis, misfolded serum apolipoprotein (apo) A-II deposits as amyloid fibrils (AApoAII) in a process associated with aging. Mouse strains carrying type C apoA-II (APOA2C) protein exhibit a high incidence of severe systemic amyloidosis. Previously, we showed that N- and C-termin...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sawashita, Jinko, Zhang, Beiru, Hasegawa, Kazuhiro, Mori, Masayuki, Naiki, Hironobu, Kametani, Fuyuki, Higuchi, Keiichi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
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PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345559/
https://ncbi.nlm.nih.gov/pubmed/25675489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416363112
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