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Constitutively active Ras negatively regulates Erk MAP kinase through induction of MAP kinase phosphatase 3 (MKP3) in NIH3T3 cells

The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, litt...

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Foilsithe in:BMB Rep
Main Authors: Park, Young Jae, Lee, Jong Min, Shin, Soon Young, Kim, Young Ho
Formáid: Artigo
Teanga:Inglês
Foilsithe: Korean Society for Biochemistry and Molecular Biology 2014
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345513/
https://ncbi.nlm.nih.gov/pubmed/24602610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2014.47.12.017
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